Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice

The biomedical application of single-walled carbon nanotubes, such as drug delivery and cancer treatment, requires a clear understanding of their fate and toxicological profile after intravenous administration

Sheng-Tao Yang

2008

Scholarcy highlights

  • The biomedical application of single-walled carbon nanotubes, such as drug delivery and cancer treatment, requires a clear understanding of their fate and toxicological profile after intravenous administration
  • SWCNTs stayed in mice over 3 months, they showed low toxicity to mice
  • The long-term accumulation of SWCNTs in the main organs was evidenced by using Raman spectroscopy and TEM technique
  • The histological observations demonstrate that slight inflammation and inflammatory cell infiltration occurred in lung, but the serum immunological indicators remained unchanged
  • No apoptosis was induced in the main organs
  • The decreasing glutathione level and increasing malondialdehyde level suggest that the toxicity of SWCNTs might be due to the oxidative stress

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