Transcriptomic profiles of the ovaries from piglets neonatally exposed to 4-tert-octylphenol

These results suggest that neonatal exposure of pigs to OP induces changes in the ovarian transcriptomic profile associated with genes encoding serine protease inhibitors and involved in steroid synthesis as well as genes linked to intracellular and membrane transport

Katarzyna Knapczyk-Stwora; Anna Nynca; Renata E. Ciereszko; Lukasz Paukszto; Jan P. Jastrzebski; Elzbieta Czaja; Patrycja Witek; Marek Koziorowski; Maria Slomczynska


Scholarcy highlights

  • Development of a healthy ovary during fetal/neonatal life is essential for future reproductive success
  • The results of the current study extended our knowledge concerning the OP effects on neonatal ovaries of the pig
  • The RNASeq approach allowed for detection of OP-induced changes in the ovarian transcriptomic profile of neonatal piglets
  • It is possible that some of the OP effects on the ovary may be partially executed by an altered lncRNA expression
  • We suggest that the differentially expressed genes identified in the ovaries of OP-treated piglets may disturb ovarian cellular function, including steroidogenesis, proliferation and apoptosis
  • The disturbances can further lead to impaired folliculogenesis in the neonatal ovary and may affect female reproduction in adulthood

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