Effect of simvastatin on vascular tone in porcine coronary artery: Potential role of the mitochondria

As statins have been shown to alter mitochondrial function, in this study we investigated the role of mitochondria in the relaxation to simvastatin

H. Almukhtar; M.J. Garle; P.A. Smith; R.E. Roberts

2016

Scholarcy highlights

  • Simvastatin, but not pravastatin, produced a slow relaxation of the coronary artery, which was independent of the endothelium
  • Statins induce acute vasorelaxation which may contribute to the overall benefits of statins in the treatment of cardiovascular disease
  • As statins have been shown to alter mitochondrial function, in this study we investigated the role of mitochondria in the relaxation to simvastatin
  • The relaxation was attenuated by the mitochondrial complex I inhibitor rotenone and the complex III inhibitor myxothiazol, or a combination of the two
  • Simvastatin and antimycin A both inhibited calcium-induced contractions in isolated blood vessels and calcium influx in smooth muscle cells and this inhibition was prevented by rotenone
  • Simvastatin produces an endothelium-independent relaxation of the porcine coronary artery which is dependent, in part, upon effects on the mitochondria
  • The effects on the mitochondria may lead to a reduction in calcium influx and relaxation of the blood vessel

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