Fibrosis biomarkers in workers exposed to MWCNTs

The results from this study revealed accumulation of inflammatory and fibrotic biomarkers in biofluids of workers manufacturing Multi-walled carbon nanotubes

Liliya M. Fatkhutdinova; Timur O. Khaliullin; Olga L. Vasil'yeva; Ramil R. Zalyalov; Ilshat G. Mustafin; Elena R. Kisin; M. Eileen Birch; Naveena Yanamala; Anna A. Shvedova

2016

Scholarcy highlights

  • Engineered carbonaceous nanomaterials present tremendous opportunities for industrial growth and development and hold great promise through their applications in medicine, electronics, and numerous other areas
  • In planning the exposure assessment, we identified critical tasks where the workers could have been exposed to aerosolized Multi-walled carbon nanotubes unloading and collection of produced MWCNTs from the reactor; ii) mechanical disintegration of MWCNTs by electric mills; iii) packaging of final products; and iv) laboratory handling of MWCNTs
  • The transmission electron microscopy images confirmed the presence of MWCNTs agglomerates ranging from0.5–10 μmat each of site, but individual nanotubes were not found
  • With the exponential growth of the manufacturing and applications of MWCNTs in major industrial fields, research and biomedicine, concerns are growing with regards to their potential adverse effects on human health
  • This is relevant to MWCNT exposures at workplaces with the highly elevated risk of occupational injury extrapolated from numerous previous in vivo animal studies showing consistent adverse lung effects including pulmonary inflammation, interstitial fibrosis and granulomatous lesions
  • We evaluated and compared levels of several potential fibrotic markers in the serum and sputum of MWCNT-exposed workers
  • Taken together these findings indicate that, if used in conjunction with pulmonary function testing and biochemical biomarkers, serum and/or sputum KL-6, TGF-β1, SPP1, as well as IL-1β levels, it could be useful for health surveillance of workers potentially exposed to carbonaceous particles in occupational settings

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