Long-term exposure to the non-steroidal anti-inflammatory drug (NSAID) naproxen causes thyroid disruption in zebrafish at environmentally relevant concentrations

Our observations show that NPX increases the risk of bioconcentration and thyroid disruption in zebrafish

Chao Xu; Lili Niu; Hangqin Guo; Xiaohui Sun; Lihui Chen; Wenqing Tu; Qizhou Dai; Jing Ye; Weiping Liu; Jinsong Liu

2019

Scholarcy highlights

  • The presence of trace levels of pharmaceuticals is an emerging issue impacting the aquatic ecosystem
  • The decrease of cytochrome P450 gene expression and enzyme activity might inhibit the metabolism of NPX, which might result in the significant bioconcentration in zebrafish
  • Significant downregulation of dio1, dio2, nis, nkx2.1, pax8, tg, tpo, trβ and ttr levels, along with the stimulation of the tshβ gene, were observed in exposed fish compared to controls
  • Western blot analysis indicated that expression of the TTR protein was significantly decreased, which coincides with the results of the gene expression analysis
  • Our observations show that NPX increases the risk of bioconcentration and thyroid disruption in zebrafish
  • Given the continued increasing consumption and emission of pharmaceuticals, thyroid disruption should be considered when assessing the aquatic risk of long-term exposure to environmentally relevant concentrations of pharmaceuticals

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