Quantitative uptake of colloidal particles by cell cultures

Immersion in biological fluids changes the physicochemical properties of colloids

Neus Feliu

2016

Scholarcy highlights

  • Immersion in biological fluids changes the physicochemical properties of colloids
  • Colloidal particles on the other hand can potentially be harmful for humans and environment
  • The review discusses aspects including how biological media could change the physicochemical properties of colloids, how colloids are endocytosed by cells, how to distinguish between internalized versus membrane-attached colloids, possible correlation of cellular uptake of colloids with their physicochemical properties, and how the colloidal stability of colloids may vary upon cell internalization
  • The metrics selected for uptake studies is of utmost importance
  • Colloids may change their physicochemical properties along their life cycle, and appropriate characterization is required during the different stages

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