Thyroid hormones as a potential early biomarker of exposure to 4-nonylphenol in adult male shubunkins (Carassius auratus)

The present study evaluated the potential effects of a single acute exposure to nonylphenol on the thyroid and reproductive axis of 250 shubunkins

A. Zaccaroni; M. Gamberoni; L. Mandrioli; R. Sirri; O. Mordenti; D. Scaravelli; G. Sarli; A. Parmeggiani

2009

Scholarcy highlights

  • Nonylphenol, an estrogenic-like compound, can induce vitellogenin synthesis in males and immature Teleostean species, but little is known about its effects on thyroid hormones balance
  • The present study evaluated the potential effects of a single acute exposure to nonylphenol on the thyroid and reproductive axis of 250 shubunkins
  • Nonylphenol induced a significant decrease of thyroxin levels, whereas no effect on triiodothyronine concentrations was detected
  • The toxicological data confirmed that nonylphenol exerts an estrogenic effect on male fish
  • The experimental design and procedures had previously been approved by the Ethical Committee of Bologna University

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