Utilization of non-invasive imaging tools for assessment of peripheral skeletal muscle size and composition in chronic lung disease: A systematic review

Skeletal muscle wasting is an important extra-pulmonary manifestation of chronic respiratory disease

Dmitry Rozenberg

2017

Scholarcy highlights

  • Skeletal muscle wasting is an important extra-pulmonary manifestation of chronic respiratory disease
  • A total of 2748 unique abstracts were identified; 87 full-text articles assessed for eligibility and 58 articles met inclusion criteria. 2254 participants with chronic respiratory disease were included
  • most US studies assessed the Cross-sectional area of the rectus femoris, using the methods described by Seymour et al
  • The majority of studies were in people with chronic obstructive pulmonary disease and focused on lower extremity muscle size, with fewer studies describing muscle fat infiltration
  • Quadriceps atrophy was independently associated with increased risk for hospital re-admission and mortality in COPD participants
  • Imaging provides an important modality for non-invasive assessment of skeletal muscle dysfunction in chronic respiratory disease
  • All three imaging modalities have been utilized to assess change in quadriceps muscle size with exercise training , which can serve as an important rehabilitation outcome in the clinical and research settings, given its close association with quadriceps strength and exercise capacity

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