An overview of male reproductive studies of boron with an emphasis on studies of highly exposed Chinese workers

We identified three categories of end points: semen analysis, reproductive outcome, and sperm Y:X ratio

Anthony R. Scialli; Jens Peter Bonde; Irene Brüske-Hohlfeld; B. Dwight Culver; Yanhong Li; Frank M. Sullivan

2009

Scholarcy highlights

  • Boron, the fifth element in the periodic table, has widespread commercial uses
  • Chinese papers were translated into English and one member of the review panel was a bilingual native of China
  • Higher doses or longer treatment periods may lead progressively to reduced sperm count, necrosis of spermatocytes, degeneration of seminiferous tubules, and testicular atrophy with loss of germ cells. These effects were first reported in 60–90-day repeated dose studies in rats given disodium tetraborate decahydrate in drinking water at doses equivalent to 25, 50, and 100 mg B/kg bw per day, in which testicular atrophy was observed at the highest dose level after 60 days treatment
  • In a continuous breeding study in mice of boric acid administered in the diet at levels equivalent to daily doses of 27, 111, or 220 mg B/kg bw, dose-related effects on the testis were noted in the mid and high dose groups; fertility was reduced at 111 mg B/kg bw/day and was absent at 220 mg B/kg bw/day
  • The panel agreed on the following conclusions regarding the male reproductive toxicity study of boron in Liaoning province: Conflict of interest
  • On an equianesthetic doses, nisoxetine produced longer action of cutaneous anesthesia than that of lidocaine or MK-801
  • Our results offer insights into the mechanisms underlying the adverse effects of B on reproduction and into the health risks posed by drinking desalinated seawater that containing elevated B concentrations
  • Sullivan has been a Consultant to U.S Borax, Borax Europe, and Rio Tinto Minerals for many years and was involved in design and interpretation of animal studies on reproductive toxicity of borates and in the interpretation of human studies on reproductive toxicity of borates

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