Antigen cocktails: valid hypothesis or unsubstantiated hope?

After more than three decades of research into the development of vaccines against parasites, a substantial number of antigens have been identified that, as purified native proteins or recombinant proteins, induce some protection against the target parasite

Peter Willadsen

2008

Scholarcy highlights

  • After more than three decades of research into the development of vaccines against parasites, a substantial number of antigens have been identified that, as purified native proteins or recombinant proteins, induce some protection against the target parasite
  • Very few achieve a degree of efficacy likely to make them candidates for single-antigen vaccines
  • Multi-antigen or ‘cocktail’ vaccines are proposed based on the assumption that such cocktails will show enhanced efficacy
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  • Et al Boophilus microplus: passage of bovine immunoglobulins and albumin across the gut of cattle ticks feeding on normal or vaccinated cattle.Res. Vet

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