Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats

We investigated preclinical effects of vortioxetine on memory in behavioral tests, and on cortical neurotransmitter levels considered important in rat memory function

Arne Mørk; Liliana P. Montezinho; Silke Miller; Crista Trippodi-Murphy; Niels Plath; Yan Li; Maria Gulinello; Connie Sanchez

2013

Scholarcy highlights

  • The serotonergic system plays an important role in cognitive functions via various 5-HT receptors
  • Preclinical studies suggest that 5-HT3 and 5-HT7 receptor antagonism as well as 5-HT1A receptor agonism may have a positive impact on cognitive functions including memory
  • We investigated preclinical effects of vortioxetine on memory in behavioral tests, and on cortical neurotransmitter levels considered important in rat memory function
  • Vortioxetine administered 1 h before or immediately after acquisition of contextual fear conditioning led to an increase in freezing time during the retention test
  • Rats treated with vortioxetine 1 h before training spent more time exploring the novel object in the novel object recognition test
  • Further demonstration of its potential effect on memory functions in clinical settings is warranted

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