Modafinil, but not escitalopram, improves working memory and sustained attention in long-term, high-dose cocaine users

This study provides initial data showing that, in a sample of long-term, high-dose cocaine users, administration of psychotropic medications, such as modafinil, can improve performance on measures of working memory

A.D. Kalechstein

2012

Scholarcy highlights

  • Sixty-one cocaine-dependent individuals were randomly assigned to receive placebo, modafinil, 200 mg, once daily, escitalopram, 20 mg, once daily, or modafinil and escitalopram, once daily, for five days on an inpatient basis
  • The purpose of the present study was to determine the effects of modafinil, escitalopram, and modafinil + escitalopram administration on neurocognition in a sample of long-term, high-dose cocaine users
  • Repeated-measures, mixed model analysis of variance showed that modafinil administration was associated with significantly improved performance on two measures of working memory span and a trend toward significant improvement on a measure of visual working memory and two measures of sustained attention, consistency of response time and reduced impulsivity
  • This study provides initial data showing that, in a sample of long-term, high-dose cocaine users, administration of psychotropic medications, such as modafinil, can improve performance on measures of working memory
  • It confirms the utility of studying the interactive effects of psychotropic medications to confirm the manner in which the candidate medications independently and interactively affect neurocognition
  • Modafinil was associated with improved performance on measures of working memory. ► Modafinil administration did not modulate performance on information processing speed. ► Modafinil administration did not modulate performance on episodic memory. ► Escitalopram did not modulate performance on measures of cognition

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