High spatial resolution increases the specificity of block-design BOLD fMRI studies of overt vowel production

The results of this paper reveal that the use of small voxels and coronal slices is best for Functional MRI studies of structured, overt vowel production, there are disadvantages associated with the use of these parameters

David A. Soltysik

2008

Scholarcy highlights

  • Echo planar imaging suffers from geometric distortion, the main source of which is magnetic field inhomogeneities
  • Block-design Functional MRI experiments of overt speech production are notorious for yielding poor activation results
  • The results of this paper reveal that the use of small voxels and coronal slices is best for fMRI studies of structured, overt vowel production, there are disadvantages associated with the use of these parameters
  • A block-design fMRI experiment was run in which subjects performed a structured, overt vowel production task
  • EPI runs were acquired with four different voxel volumes and three different slice orientations in an attempt to find the optimum acquisition parameters that maximize specificity
  • Results indicated that the use of small voxel volumes yielded a significantly higher percentage of true positive activation compared to the use of larger voxel volumes
  • Combining the strategy of high spatial resolution with an optimum task duration and post-processing methods to separate true and false positives has been found to greatly improve the specificity of single-subject, block-design Functional MRI studies of structured, overt vowel production

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