PBN fails to suppress in delayed neuronal death of hippocampal CA1 injury following transient forebrain ischemia in gerbils

In the present study, we evaluated the effect of phenyl-N-tert-butyl nitrone on delayed neuronal death and on the levels of free radicals in hippocampal CA1 region in the gerbil

Wael Goda

2012

Scholarcy highlights

  • Free radicals have been suggested to be involved in the genesis of ischemic brain damage, as shown by the protective effects of alpha-phenyl-N-tert-butyl nitrone, a spin trapping agent, in ischemic cerebral injury
  • In the present study, we evaluated the effect of PBN on delayed neuronal death and on the levels of free radicals in hippocampal CA1 region in the gerbil
  • We observed no free radical formation in delayed neuronal death, determined immunohistochemically using a specific 8-OHdG antibody, after transient ischemic insult. These results suggest that free radical formation may not contribute to the formation of delayed neuronal death
  • ► PBN failed to show any preventive effect on the delayed neuronal death. ► No free radical formation was observed after transient ischemic insult. ► Free radical formation may not contribute to the delayed neuronal death

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