Barium tungstate nanoparticles to enhance radiation therapy against cancer

We investigated BaWO4 nanoparticles as a novel type of alkaline-earth metal tungstate radiosensitizer for radiotherapy

Renjie Wang; Zhengwei Cao; Lan Wei; Lin Bai; Hui Wang; Shiyi Zhou; Shuyue Zhan; Bin Ji; Zibo Li; Shi Gao; Jin Xie; Qingjie Ma

2020

Scholarcy highlights

  • High-Z nanoparticles have emerged as a novel type of radiosensitizers due to their relatively large X-ray cross-section and ability to enhance radical production under irradiation
  • We found that BaWO4 nanoparticles could more efficiently enhance hydroxyl radical production under irradiation than CaWO4 nanoparticles
  • BaWO4 nanoparticles led to more efficient tumor inhibition without causing systemic toxicity
  • Our results suggest that BaWO4 nanoparticles can efficiently enhance RT and hold great potential as a novel type of radiosensitizing agent
  • Our results show that BaWO4 nanoparticles have lower toxicity than CaWO4 nanoparticles in the absence of radiation but lead to higher cellular oxidative stress in vitro and greater tumor suppression in vivo

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