Glucosamine-conjugated graphene quantum dots as versatile and pH-sensitive nanocarriers for enhanced delivery of curcumin targeting to breast cancer

The higher cytotoxicity of Cur/GlcN-graphene quantum dots against MCF-7 cells compared to Cur/GQDs were observed

Narges Ghanbari; Zeinab Salehi; Abbas Ali Khodadadi; Mohammad Ali Shokrgozar; Ali Akbar Saboury

2020

Scholarcy highlights

  • The higher cytotoxicity of Cur/GlcN-graphene quantum dots against MCF-7 cells compared to Cur/GQDs were observed
  • The biocompatible photoluminescent GQDs were synthesized from graphene oxide through the green and facile oxidizing method
  • The MTT assay results demonstrated the nontoxicity of the bare nanocarrier with the cell viability of above 94% even at concentrations as high as 50 μg·ml−1, while the Cur/GlcN-GQDs exhibited much more cytotoxicity against MCF-7 cells compared to Cur/GQDs
  • The MTT assay results demonstrated the nontoxicity of the bare nanocarrier with the cell viability of above 94% even at concentrations as high as 50 μg·ml−1, while the Cur/GlcN-graphene quantum dots exhibited much more cytotoxicity against MCF-7 cells compared to Cur/GQDs. It is reasonable to conclude that this advanced multifunctional nano-assembly offers superior potential for breast cancer cell-targeted delivery

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