MUC-1 aptamer conjugated InP/ZnS quantum dots/nanohydrogel fluorescent composite for mitochondria-mediated apoptosis in MCF-7 cells

We report on the synthesis of NHG-quantum dots nanosystem conjugated with an amino-modified MUC-1 aptamer and loaded with hydrophobic paclitaxel

Zahra Ranjbar-Navazi; Marziyeh Fathi; Elaheh Dalir Abdolahinia; Yadollah Omidi; Soodabeh Davaran

2020

Scholarcy highlights

  • The combined use of nanohydrogels and quantum dots has resulted in the development of a nanoscaled drug delivery system with fluorescence imaging potential
  • NHG-QDs composite loaded with anti-cancer drugs could be applied as an effective theranostics for simultaneous diagnosis and therapy of cancer cells
  • To effectively target and eradicate breast cancer MCF-7 cells, the nanocomposite was further loaded with the inhibitor of lactate dehydrogenase, sodium oxamate to inhibit the conversion of pyruvate to lactate via LDH and disrupting glycolysis
  • The Ap-NHG-QDs-PTX-SO NS is proposed to serve as a robust theranostics for simultaneous imaging and therapy of breast cancer and other types of solid tumors

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