Manganese superoxide dismutase vs. p53: Regulation of mitochondrial ROS

Coordination of mitochondrial and nuclear activities is vital for cellular homeostasis, and many signaling molecules and transcription factors are regulated by mitochondria-derived reactive oxygen species to carry out this interorganellar communication

Aaron K. Holley; Sanjit Kumar Dhar; Daret K. St. Clair

2010

Scholarcy highlights

  • Coordination of mitochondrial and nuclear activities is vital for cellular homeostasis, and many signaling molecules and transcription factors are regulated by mitochondria-derived reactive oxygen species to carry out this interorganellar communication
  • Recent evidence suggests mitochondrial regulation of p53 activity through mechanisms that affect reactive oxygen species production, and a breakdown of communication amongst mitochondria, p53, and the nucleus can have broad implications in disease development

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