Regulation of iodothyronine deiodinases and sodium iodide symporter mRNA expression by perchlorate in larvae and adult Chinese rare minnow (Gobiocypris rarus)

The results showed that deflation of swim bladder development was observed in larvae at 50 μg/L perchlorate treatment

Wei Li; Jinmiao Zha; Lihua Yang; Zhaoli Li; Zijian Wang

2011

Scholarcy highlights

  • Perchlorate is a widespread contaminant in the aquatic environment
  • The results showed that deflation of swim bladder development was observed in larvae at 50 μg/L perchlorate treatment
  • An up-regulation of the d2 and nis mRNA levels were observed in the larve and in brain of adults
  • The expressions of d3 mRNA levels were significantly down-regulated in the liver
  • These results indicate the changes in d2, nis, and d3 mRNA expression brings about increased outer-ring deiodination, idodine uptake, and a further decrease of inner-ring deiodination, respectively reflecting auto-regulation of hypothalamic-pituitary-thyroid axis in adult after perchlorate exposure
  • ► Inner-ring deiodination was decreased in the liver of adult fish

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