Mitochondria and cellular redox state on the route from ageing to Alzheimer’s disease

Mitochondria and redox homeostasis are intimately correlated in ageing process

G. Abate; M. Vezzoli; M. Sandri; W. Rungratanawanich; M. Memo; D Uberti

2020

Scholarcy highlights

  • Mitochondria and redox homeostasis are intimately correlated in ageing process
  • Despite some controversies and still huge open questions, a growing body of evidence suggest alterations of mitochondrial functionality and redox-homeostasis occur during the ageing process
  • Oxidative damage and mitochondrial dysfunction do not represent the cause of ageing per se but they have to be analyzed within the complexity of those series of processes occurring during lifespan
  • We discuss the crosstalk between mitochondria and cytosolic-ROS
  • Through a visual data mining approach, we attempt to describe the dynamic interplay between mitochondria and cellular redox state on the route from ageing to an AD phenotype

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