Association of CCR5, TLR2, TLR4 and MBL genetic variations with genital tract infections and tubal factor infertility

This study focused on four polymorphisms in the mannose binding lectin gene and assessed their significance in tubal damage and female fertility by comparing genotype frequencies among 388 controls and women with tubal factor infertility or previous ectopic pregnancy

Triin Laisk; Maire Peters; Merli Saare; Kadri Haller-Kikkatalo; Helle Karro; Andres Salumets

2010

Scholarcy highlights

  • Tubal factor infertility is one of the most common causes of female infertility characterized by uni- or bilateral blockage or scarring of the Fallopian tubes mainly attributable to pelvic inflammatory disease
  • The CCR5, TLR2 and TLR4 genotypes were not associated with tubal factor infertility, the TLR4 Asp299Gly and Thr399Ile heterozygosity was associated with a decreased incidence of pathogens associated with genital tract infections in tubal factor infertility patients
  • These data suggest that polymorphisms in TLR4 and MBL2 play a role in receptiveness to pathogens causing genital tract infections, while MBL2 genotypes contribute to susceptibility to tubal factor infertility
  • Of the nine polymorphisms selected, only MBL2 −550 H/L was associated with TFI
  • The high-producing MBL2 genotype HYA/HYA and the low-producing MBL2 genotype group were both associated with susceptibility to TFI, whereas another high-producing MBL2 genotype HYA/LYA was found to have a protective effect
  • The causes of TFI were as follows: unspecified blockage and/or surgery of Fallopian tubes, sacto- or hydrosalpinx, adhesions, and abscess
  • This study focused on four polymorphisms in the mannose binding lectin gene and assessed their significance in tubal damage and female fertility by comparing genotype frequencies among 388 controls and women with tubal factor infertility or previous ectopic pregnancy
  • Our purpose was to investigate a possible relationship between severe early childhood caries and polymorphism of the mannose binding lectin gene and investigate the role of allele variant as a possible factor in the susceptibility to S-ECC

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