One-step electrodeposition synthesis of bisphosphonate loaded magnesium implant: A strategy to modulate drug release for osteoporotic fracture healing

A novel one-step electrodeposition synthesis of drug loaded coating was proposed in this study

Peng Wan

2020

Key concepts

Scholarcy highlights

  • A novel one-step electrodeposition synthesis of drug loaded coating was proposed in this study
  • Bisphosphonates were widely recommended as effective clinical treatment drugs
  • Combination of biodegradable Mg-based implants and merits of bisphosphonates was suggested for osteoporotic fracture healing
  • Considering the mild and sustained drug release, a novel one-step electrodeposition synthesis of drug loaded coating was proposed in this study
  • The in vitro cell response to zoledronate loaded coating showed enhanced proliferation and osteogenic differentiation of osteoblasts and no significant inhibition on osteoclasts, which could improve bone-forming and decrease bone resorption due to osteoporosis

Need more features? Save interactive summary cards to your Scholarcy Library.