Increasing Comorbidities Suggest that Atopic Dermatitis Is a Systemic Disorder

The immune-mediated skin disease atopic dermatitis has long been recognized as closely associated with other atopic conditions

Patrick M. Brunner; Jonathan I. Silverberg; Emma Guttman-Yassky; Amy S. Paller; Kenji Kabashima; Masayuki Amagai; Thomas A. Luger; Mette Deleuran; Thomas Werfel; Kilian Eyerich; Georg Stingl; Martine Bagot; Dirk Jan Hijnen; Michael Ardern-Jones; Nick Reynolds; Phyllis Spuls; Alain Taieb

2016

Scholarcy highlights

  • The immune-mediated skin disease atopic dermatitis has long been recognized as closely associated with other atopic conditions
  • Councilors of the International Eczema Council, all leaders in AD research, gathered at the Annual European Society for Dermatological Research meeting in 2015 to review the increasingly recognized comorbidities, including controversial associations, that may contribute to the burden of AD
  • Presenters searched for AD/eczema studies from 2000 through 2016 using PubMed, Google scholar, Science direct, and ClinicalTrials.gov using keywords such as atopic dermatitis or eczema combined with infection, cardiovascular, neuro-psychiatric, and malignant
  • ATOPIC DERMATITIS AND EPIDEMIOLOGIC ASSOCIATIONS Cardiovascular risks Analogous to psoriasis, recent studies have suggested an association between AD, obesity, and cardiovascular disease in both adults and pediatric patients
  • Nonfatal stroke was significantly increased in female U.S.-based nurses with history of ever having AD when controlling for age but not after controlling for hypertension, hypercholesterolemia, and diabetes; nonfatal myocardial infarction was not increased. These studies suggest that poor health behaviors and increased cardiovascular risk factors are the major drivers of cardiovascular disease and events in patients with AD, rather than systemic inflammation
  • Moderate to severe pediatric AD has significantly higher systolic and diastolic blood pressures and significantly higher odds of systolic blood pressure at or above the 90th percentile
  • As new treatment approaches for AD are being developed, monitoring of patients longitudinally to determine the impact of these approaches on AD-associated comorbidities, in addition to skin manifestations, will likely reveal mechanisms of disease associations and result in the development of more targeted, or even personalized, treatment approaches

Need more features? Save interactive summary cards to your Scholarcy Library.