Effects of non-steroidal anti-inflammatory drugs on hormones and genes of the hypothalamic-pituitary-gonad axis, and reproduction of zebrafish

The results demonstrated that ibuprofen could modulate hormone production and related gene transcription of the HPG axis in a sex-dependent way, which could cause adverse effects on reproduction and the development of offspring

Kyunghee Ji; Xiaoshan Liu; Saeram Lee; Sungeun Kang; Younglim Kho; John P. Giesy; Kyungho Choi

2013

Scholarcy highlights

  • Parental exposure to ibuprofen resulted in delayed and lesser rates of hatching
  • This study was conducted in two experiments, to identify non-steroidal anti-inflammatory drugs with high endocrine disruption potentials, and to understand consequences of exposure to such NSAIDs in fish
  • Significant up-regulation of fshβ, lhβ, fshr and lhr were observed in females, whereas down-regulation was observed in males exposed to each NSAID
  • Ibuprofen was chosen as a model chemical
  • Adult zebrafish pairs were exposed to ibuprofen for 21 d, and the effects on reproduction and development of offspring were examined
  • The results demonstrated that ibuprofen could modulate hormone production and related gene transcription of the HPG axis in a sex-dependent way, which could cause adverse effects on reproduction and the development of offspring

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