Potentiality of standardized extract and isolated flavonoids from Zuccagnia punctata for the treatment of respiratory infections by Streptococcus pneumoniae: In vitro and in vivo studies

The present study has shown that intake once or twice a day of 1 mg of Zuccagnia punctata extract or HF for seven days did not result in toxicity

I.C. Zampini

2012

Scholarcy highlights

  • The aim of this study was to demonstrated the antibacterial activity of the Zuccagnia punctata standardized extract and the structurally related non-methoxylated flavonoids with similar pattern of substitution and differences in ring C present in this plant species: 7-hydroxyflavanone, 2′,4′-dihydroxychalcone and 3,7-dihydroxyflavone, against Streptococcus pneumoniae clinical isolates using in vitro and in vivo models
  • The present study has shown that intake once or twice a day of 1 mg of Zuccagnia punctata extract or HF for seven days did not result in toxicity
  • Our results showed that Zuccagnia punctata extract as well as one of its isolated flavonoids, 7-hydroxyflavanone, could be useful for the development of a novel respiratory infections treatment
  • The aim of this study was to evaluate the antibacterial activity of Zuccagnia punctata standardized extracts and three compounds isolated from this plant species against Streptococcus pneumoniae clinical isolates
  • In vitro and in vivo models were used

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