Characterisation of mechanical insertion of commercial microneedles

This study evaluates the influence of biaxial skin strain on the insertion force of two different microneedling systems into the skin

Akmal H. Sabri; Zachary Cater; Jane Ogilvie; David J. Scurr; Maria Marlow; Joel Segal

2020

Scholarcy highlights

  • The human skin is the largest organ in the human body and is comprised of three layers; the epidermis, dermis and hypodermis
  • This study evaluates the influence of biaxial skin strain on the insertion force of two different microneedling systems into the skin
  • For all the skin strain levels investigated, it was evident that the Dermapen® required less insertion force than the DermastampTM
  • In contrast for the DermastampTM, the percentage of successful microneedle insertions increases with strain before decreasing at higher strain rate
  • In terms of insertion depth, it was apparent that the penetration of the Dermapen® was much deeper than that of the DermastampTM
  • This work aligns with our findings that the commercial microneedle systems were capable of penetrating Parafilm M® layers up to circa 60% of the microneedle length
  • The lower insertion force and deeper penetration provided by the Dermapen® was attributed to the oscillating feature of the microneedle system which mitigates the effective frictional force experienced by the needle during skin insertion

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