Redox dual-responsive dendrimeric nanoparticles for mutually synergistic chemo-photodynamic therapy to overcome drug resistance

Combination therapy has exhibited crucial potential in the treatment of cancers, especially in drug-resistant cancers

Dan Zhong; Huayu Wu; Yahui Wu; Yunkun Li; Jun Yang; Qiyong Gong; Kui Luo; Zhongwei Gu

2020

Scholarcy highlights

  • Combination therapy has exhibited crucial potential in the treatment of cancers, especially in drug-resistant cancers
  • A novel tumor-targeted, redox dual-responsive and paclitaxel loaded nanoparticle based on multifunctional dendrimer and lentinan was developed for combinational chemo-photodynamic therapy of PTX-resistant cancers
  • The combination of PTX and photodynamic treatment lead to excellent antitumor effects to drug-resistant A549/T cells in vitro and in vivo, which provides a new strategy for the design of co-delivery system to overcome drug resistance

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