Well-defined polymer-drug conjugate engineered with redox and pH-sensitive release mechanism for efficient delivery of paclitaxel

We develop a novel anti-cancer polymer–drug conjugate engineered with side groups of disulfide and ester bonds for on-demand delivery of paclitaxel with redox and pH dual sensitive behaviors

Shixian Lv

2014

Scholarcy highlights

  • The synthesis of polymer–drug conjugate capable of convenient preparation and controlled release of therapeutic agents is still an urgent requirement in drug delivery field
  • We develop a novel anti-cancer PDC engineered with side groups of disulfide and ester bonds for on-demand delivery of paclitaxel with redox and pH dual sensitive behaviors
  • The in vivo studies on B16F1 melanoma bearing C57BL/6 mice demonstrated the superior antitumor activity of P(L-SS-PTX) over both free PTX and P(L-PTX). This dual-sensitive prodrug provides a useful strategy for anti-tumor drug delivery
  • A well-defined polymer–drug conjugate with redox and pH-sensitive drug release feature was developed for efficient delivery of paclitaxel

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