Reduction of protein adsorption to a solid surface by a coating composed of polymeric micelles with a glass-like core

Adsorption studies by optical reflectometry show that complex coacervate core micelles composed of poly( hydrochloride)49-block-poly(ethylene oxide)212 and poly( sodium salt)47-block-poly(ethylene oxide)212 adsorb in equal amounts to both silica and cross-linked 1,2-polybutadiene

B. Hofs

2008

Scholarcy highlights

  • Adsorption studies by optical reflectometry show that complex coacervate core micelles composed of poly( hydrochloride)49-block-poly(ethylene oxide)212 and poly( sodium salt)47-block-poly(ethylene oxide)212 adsorb in equal amounts to both silica and cross-linked 1,2-polybutadiene
  • Experiments were performed with different types of surfaces, solvents, and proteins; bare silica and cross-linked 1,2-PB, NaNO3 and phosphate buffer, and lysozyme, bovine serum albumin, β-lactoglobulin, and fibrinogen
  • Reduction is better in phosphate buffer than in NaNO3, except for the positively charged lysozyme, where the effect is reversed

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