Cellular calcium signaling in the aging brain

Aging in the biological system is an irreversible process

Remya Chandran; Mantosh Kumar; Lakshmi Kesavan; Reena Sarah Jacob; Sowmya Gunasekaran; Sethu Lakshmi; C. Sadasivan; R.V. Omkumar

2017

Scholarcy highlights

  • Aging in the biological system is an irreversible process
  • Aging is associated with changes in several cellular and molecular functions among which calcium signaling is a prominent one
  • Calcium signaling is essential for many vital functions of the brain and even minor impairments in calcium signaling can lead to deleterious consequences including neuronal death
  • Calcium signaling proteins are pursued as promising drug targets for many aging related diseases
  • This review attempts to summarize changes in calcium signaling in the brain as a result of aging

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