Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review

Though the prospect of Smart Drug Delivery System is quite promising, the toxicity of nanocarriers in human organs is a major concern; this review presents a table of eight nanocarriers summarized in terms of their toxicity and biocompatibility

Sarwar Hossen; M. Khalid Hossain; M.K. Basher; M.N.H. Mia; M.T. Rahman; M. Jalal Uddin

2018

Scholarcy highlights

  • Cancer is the second leading cause of death worldwide
  • Though the prospect of Smart Drug Delivery System is quite promising, the toxicity of nanocarriers in human organs is a major concern; this review presents a table of eight nanocarriers summarized in terms of their toxicity and biocompatibility
  • To conquer the limitations associated with conventional chemotherapy, smart nanocarrier-based drug delivery systems, known as SDDSs. have been introduced
  • There are still many challenges ahead for SDDSs to be effectively applied as a promising alternative to chemotherapy for cancer treatment; the technology behind SDDSs is under continuous research
  • This review considers the gravity of toxicity and makes a bio-distribution assessment of the eight most common nanocarriers used in SDDSs
  • The toxicity suggests that more extensive research is needed for SDDSs
  • The toxicity suggests that more extensive research is needed for Smart Drug Delivery System. The associated challenges and future research scope in SDDSs, which may favor the enduring perspectives and development of nanocarrier-based SDDSs for cancer treatment, have been discussed

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