Interventions for Treating Sarcopenia: A Systematic Review and Meta-Analysis of Randomized Controlled Studies

Much interest has been focused on interventions for treating sarcopenia; the effects have gained little evidence

Yoshihiro Yoshimura

2017

Scholarcy highlights

  • Much interest has been focused on interventions for treating sarcopenia; the effects have gained little evidence
  • We screened a total of 2668 records and included seven randomized controlled trials that investigated the effects of exercise, nutrition, drug, and combination on muscle mass, strength, and function in older people with sarcopenia
  • Very low to low-quality evidence suggests that exercise interventions may play a role in improving muscle mass, muscle strength, and walking speed in 3 months of intervention; nutritional interventions may be effective in improving muscle strength in 3 months of intervention; as drug intervention, selective androgen receptor modulator had no clear effect on muscle mass, strength, and physical function; and a combined intervention of exercise and nutrition may have positive effects in improving the walking speed in 3 months of intervention
  • Our systematic review and meta-analysis showed some positive effects of exercise and nutritional interventions for treating sarcopenia in older people, the quality of the evidence was low
  • H.A. has accepted honoraria of ≥500,000 yen in total annual income from each company, and has accepted clinical research funding of ≥1,000,000 yen in total annual research grants paid from a single company
  • All authors are members of the Japanese Association on Sarcopenia and Frailty

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