A meta-analysis of cognitive deficits in first-episode Major Depressive Disorder

Recurrent-episode Major Depressive Disorder is associated with a number of neuropsychological deficits

Rico S.C. Lee; Daniel F. Hermens; Melanie A. Porter; M. Antoinette Redoblado-Hodge

2011

Scholarcy highlights

  • Recurrent-episode Major Depressive Disorder is associated with a number of neuropsychological deficits
  • The current aim was to systematically evaluate the literature on first-episode MDD to determine whether cognition may be a feasible target for early identification and intervention
  • Effect sizes were pooled by cognitive domain
  • Inpatient status, antidepressant use, age and educational attainment, each significantly contributed to heterogeneity in effect sizes in at least one cognitive domain
  • Psychomotor speed and memory functioning were associated with clinical state, whereas attention and executive functioning were more likely trait-markers
  • Cognitive deficits appear to be feasible early markers and targets for early intervention in Major Depressive Disorder

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