Genomic signature of accelerated evolution in a saline-alkaline lake-dwelling Schizothoracine fish

We found elevated genome-wide rate of molecular evolution in G. przewalskii relative to lowland teleost fish species

Chao Tong; Miao Li

2020

Scholarcy highlights

  • Environments may shape the genetic landscape of wildlife that inhabit them
  • Our comparative genomics study identified a set of rapidly evolving ion transport genes and transcriptomic signatures in Schizothoracine fish adaptation to saline and alkaline environment on the Keywords: Comparative genomics, Schizothoracinae, Accelerated evolution, Saline and alkaline adaptation aCC-BY-NC-ND 4.0 International license
  • After identification of orthologs according to the curated orthologous gene groups of Actinopterygii in each fish species, we obtained a total of 74,107 putative orthologs in 16,379 orthologous gene groups
  • We used comparative genomics based on the de novo assemblies from pooled six tissues transcriptomes to identify the genomic signature of saline and alkaline adaptation in a highland fish, G. przewalskii
  • These putative genomic signatures included: Schizothoracine fish, G. przewalskii had an elevated genome-wide nucleotide substitution rate than lowland teleost fish species; a number of genes associated with ion transport and energy metabolism functions were found in G. przewalskii with elevated molecular evolutionary rate showing the signature of rapidly evolving; most of rapidly evolving ion transport genes associated with sodium ion transport, calcium ion transport and chloride transport were broadly expressed in kidney, gill, liver, spleen, brain and muscle of G. przewalskii; A
  • Our present study will provide the genomic signatures of rapidly evolving ion transport genes, and gain the insights into the saline and alkaline adaptation of highaltitude dwelling fishes

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