Methanol, ethyl acetate and n-hexane extracts of Tragia involucrata L. leaves exhibit anxiolytic, sedative and analgesic activity in Swiss albino mice

We examined the anxiolytic and sedative activity of crude methanol, ethyl acetate and n-Hexane extract of Tragia involucrata L. leaves using mouse behavioral models such as elevated plus-maze test and pentobarbital-induced sleeping time test, respectively

Md. Shofiqul Islam

2021

Scholarcy highlights

  • Tragia involucrata L. have been utilized as traditional medicine in Indian subcontinent for the treatment of numerous illnesses such as inflammation, pain and skin infection
  • Using Elevated plus maze test assay, we found that administration of different group of TIME, TIEAE and TIHE induced an anxiolytic-like effect in mice as demonstrated by increased open arm entries and the time spent in the open arms compared to control
  • The phytochemical screening revealed that the Tragia involucrata L. leaves extracts contain flavonoids, alkaloids and saponins which perhaps interact with the COX receptors and other inflammatory and neurogenic pain modulators
  • This study examined various pharmacological properties of the Tragia involucrata L. leaves using elevated plus maze, pentobarbital induced sleeping time, acetic acid induced writhing and formalin induced pawlicking tests
  • Findings from this study demonstrate that Tragia involucrata L. has significant anxiolytic, analgesic and sedative effects
  • This study detects the presence of numerous secondary metabolites along with the presence of heavy metals in Tragia involucrata L. leaves that may be insightful for real-life applications

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