Wide-gene expression analysis of lipid-relevant genes in nutritionally challenged gilthead sea bream (Sparus aurata)

At least in gilthead sea bream, this metabolic feature is changing with the advent of new fish feed formulations, and our results demonstrate high expression of FADS2 in the liver of fish fed continuously when comparisons are made with other lipid-related genes

Laura Benedito-Palos

2014

Scholarcy highlights

  • Whereas global fisheries are in decline, the aquaculture industry is continuously growing and several efforts have been directed towards the reduction of wild-fisheryderived raw materials in the feeds of farmed fish
  • ATGL seems to be regulated at the transcriptional level, and its expression was significantly up-regulated in the liver of fasted fish following the increased gene expression of oxidative enzymes involved in fatty acid β-oxidation
  • The present study analyses how 40 genes selected as markers of lipid and lipoprotein metabolism are regulated in concert in fish challenged by fasting
  • The results clearly show a tissue-specific regulation according to the different metabolic capabilities of each tissue and vital functions for life, which makes the brain highly refractory at the transcriptional level to changes in nutrient and energy availability
  • The two isoforms of LPL have been confirmed as key enzymes of lipid metabolism in fish, with a differential and tissue-specific gene expression pattern in adipogenic and muscle tissues. This kind of differential tissue regulation has been reported for most of the genes included in the array, which is of interest when defining the set of the most informative lipid markers for a given tissue and experimental condition
  • This knowledge will contribute to define in future studies how the different tissue-specific gene expression patterns are segregated with the selection pressure for fast growth and alternative diets on intensive fish farming

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