Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) in Asian seabass, Lates calcarifer: Cloning, ontogeny and expression analysis following bacterial infection or ligand stimulation

We have identified and cloned NOD1 transcript in the Asian seabass, Lates calcarifer, which consists of 3749 nucleotides and encodes for a predicted putative protein of 900 AA

Anutosh Paria; M. Makesh; Aparna Chaudhari; C.S. Purushothaman; K.V. Rajendran

2018

Scholarcy highlights

  • AsNOD1 might have both antiviral and antibacterial functions in marine euryhaline teleost
  • NOD1 is one of the most prominent intracellular Nod-like receptors, responsible for detecting different microbial components and products arising from tissue injury
  • We have identified and cloned NOD1 transcript in the Asian seabass, Lates calcarifer, which consists of 3749 nucleotides and encodes for a predicted putative protein of 900 AA
  • From the ontogenetic expression profile of AsNOD1, it is quite evident that this gene might follow a maternally-transferred trend in euryhaline teleosts, as it is highly abundant in embryonic developmental stages
  • The constitutive immunomodulation of AsNOD1 in terms of expression level was clearly evident in the different tissues of Asian seabass-injected either with Vibrio alginolyticus or poly I:C
  • Based on the results obtained in the present study, it can be inferred that the AsNOD1 might play an immunoregulatory role upon exposure to different bacterial as well as viral PAMPs and might be an important component of innate immune element during embryonic and larval development in the euryhaline teleost Asian seabass

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