Effects of anti-inflammatory drugs in primary kidney cell culture of a freshwater fish

This study aimed to evaluate toxic effects of some representative drugs of this pharmaceutical group on primary culture of monocytic lineage of Hoplias malabaricus anterior kidney

João Luiz Coelho Ribas

2014

Scholarcy highlights

  • The non-steroidal anti-inflammatory drugs are emerging contaminants in aquatic ecosystems
  • This study aimed to evaluate toxic effects of some representative drugs of this pharmaceutical group on primary culture of monocytic lineage of Hoplias malabaricus anterior kidney
  • Cytometry analysis CD11b+ cells showed 71.5% of stem cells, 19.5% of macrophages and 9% of monocytes
  • Cell viability was lower in the ficoll compared to percoll separation
  • Genotoxicity occurred at the highest concentration of diclofenac and at the intermediary concentration of acetaminophen
  • The pharmaceuticals influenced NO production and caused DNA damage in monocytic cells suggesting that these drugs can induce immunosuppression and genotoxicity in fish

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