Coenzyme Q redox signalling and longevity

We review how Mitochondrial Reactive Oxygen Species are generated in young and old mitochondria and how complex I and complex III derived Reactive Oxygen Species control physiological and pathological processes

Filippo Scialo; Alberto Sanz

2021

Scholarcy highlights

  • Mitochondria are the powerhouses of the cell
  • We know that Mitochondrial Reactive Oxygen Species are essential redox messengers required to determine cell fate and maintain cellular homeostasis
  • Most mtROS are produced by respiratory complex I and complex III
  • There is an accumulation of defective mitochondria that generate high levels of mtROS
  • We discuss why damaged mitochondria amass during ageing as well as methods to preserve mitochondrial redox signalling with age

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