Mitochondrial calcium transport and the redox nature of the calcium-induced membrane permeability transition

Mitochondria possess a Ca2+ transport system composed of separate Ca2+ influx and efflux pathways

Anibal E. Vercesi; Roger F. Castilho; Alicia J. Kowaltowski; Helena C.F. de Oliveira; Nadja C. de Souza-Pinto; Tiago R. Figueira; Estela N.B. Busanello

2018

Scholarcy highlights

  • Mitochondria possess a Ca2+ transport system composed of separate Ca2+ influx and efflux pathways
  • Intramitochondrial Ca2+ concentrations regulate oxidative phosphorylation, required for cell function and survival, and mitochondrial redox balance, that participates in a myriad of signaling and damaging pathways
  • We discuss the regulation of the permeability transition pore by mitochondrial oxidants, reactive nitrogen species, and the interactions between these species and other PTP inducers
  • We discuss the involvement of mitochondrial redox imbalance and PTP in metabolic conditions such as atherogenesis, diabetes, obesity and in mtDNA stability

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