Uncoupling proteins and the control of mitochondrial reactive oxygen species production

Reactive oxygen species, natural by-products of aerobic respiration, are important cell signaling molecules, which left unchecked can severely impair cellular functions and induce cell death

Ryan J. Mailloux; Mary-Ellen Harper

2011

Scholarcy highlights

  • Reactive oxygen species, natural by-products of aerobic respiration, are important cell signaling molecules, which left unchecked can severely impair cellular functions and induce cell death
  • Cells have developed a series of systems to keep ROS in the nontoxic range
  • We have confirmed that ROS activate UCP2 and UCP3, and demonstrated that UCP2 and UCP3 are controlled by covalent modification by glutathione
  • Our findings are consistent with the notion that Uncoupling proteins 2 and 3 are acutely activated by ROS, which directly modulate the glutathionylation status of the UCP to decrease ROS emission and participate in cell signaling mechanisms

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