Intermingling of gut microbiota with brain: Exploring the role of probiotics in battle against depressive disorders

We provide an overview of physiological alleyways involved in cross-talk between gut and brain, part played by probiotics in regulation of these pathways and use of probiotic bacteria as psychobiotics in various mental or depressive disorders

Priya Tyagi; Mohd Tasleem; Shweta Prakash; Garima Chouhan

2020

Scholarcy highlights

  • Major Depressive disorder and comorbid neuropsychiatric conditions are leading cause of disability worldwide
  • Discovery of gut microbes as our mutualistic partner was made a long time ago and it is surprising that their functions still continue to expand and as of yet many are still to be uncovered
  • Experimental studies have revealed astonishing role of gut commensals in gut-brain signaling, immune homeostasis and hormonal regulation. It is a well-established fact that gut microbes can alleviate stress or depression associated symptoms by modulating brain functions
  • We provide an overview of physiological alleyways involved in cross-talk between gut and brain, part played by probiotics in regulation of these pathways and use of probiotic bacteria as psychobiotics in various mental or depressive disorders

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