Male obesity and alteration in sperm parameters

After institutional review board approval, we reviewed records of all couples who presented to a tertiary care center for infertility evaluation in the last 2 years and who had a semen analysis

Ahmad O. Hammoud; Nicole Wilde; Mark Gibson; Anna Parks; Douglas T. Carrell; A. Wayne Meikle

2008

Scholarcy highlights

  • The mean age of the study population was 32.8 ± 0.3 years
  • It is unclear how the findings of poorer measures of semen quality in cohort studies relate to the increased interpregnancy intervals found among couples with obese male partners; causes for this relationship might include behavioral, sexual dysfunction, or semen quality factors
  • The purpose of this study was to investigate the relationship between BMI, measures of semen quality, and male sexual dysfunction in couples presenting for evaluation of infertility
  • After exclusion of patients with known male factor, the BMI data were available for 83% of male patients
  • The odds ratio of having a progressively motile sperm count <10 × 106 in obese patients compared with normal-weight patients was 3.4
  • A logistic regression model that corrected for age, smoking, alcohol use, antidepressant use, and BMI showed that age and intake of antidepressant were the only significant determinants of the presence of erectile dysfunction
  • When 5 × 106 progressively motile sperm was used as the threshold for defining low total progressively motile sperm count, we obtained similar results: the prevalence of such counts was 3.2% among men with normal weight, 6.5% for overweight men, and 10.9% for obese men. When we compared obese patients with non-obese patients, the OR of having a high percentage of abnormal morphology was 1.6
  • The use of absolute frequencies in this population no doubt overestimates the incidence of abnormal sperm parameters in relation to overweight and obesity

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