Methylated N-(4-N,N-dimethylaminobenzyl) chitosan coated liposomes for oral protein drug delivery

with liposomes entrapped with fluorescein isothiocyanate-conjugated bovine serum albumin

Jariya Kowapradit

2012

Scholarcy highlights

  • with liposomes entrapped with fluorescein isothiocyanate-conjugated bovine serum albumin
  • Liposomes composed of 10:2 molar ratios of egg yolk phosphatidylcholine and sodium oleate were prepared by a thin film hydration method
  • TM56Bz42CS-coated liposomes were evaluated for their protein transport efficiencies and cytotoxicities in Caco-2 cells
  • stabilities of the TM56Bz42CS-coated LP-BSA were determined by examining the degradation of the protein in simulated intestinal fluid containing
  • The results of the FITC-BSA transport showed that the TM56Bz42CS-coated FITC-BSA-LP enhanced protein permeability across the Caco-2 cell monolayers with low cytotoxicity
  • In the present study, methylated N-(4-N,N-dimethylaminobenzyl) chitosan was synthesised and investigated for oral protein drug delivery by combining it with liposomes entrapped with fluorescein isothiocyanate-conjugated bovine serum albumin, a model protein

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