Chondroitin-based nanoplexes as peptide delivery systems – Investigations into the self-assembly process, solid-state and extended release characteristics

CHON/PROT NPs were successfully obtained with properties that were dependent on the concentration of the polyelectrolytes and their mixing ratio

Anita Umerska

2015

Scholarcy highlights

  • CHON/PROT NPs were successfully obtained with properties that were dependent on the concentration of the polyelectrolytes and their mixing ratio
  • X-ray diffraction determined the amorphous nature of the negatively charged NPs, while those with the positive surface potential were semi-crystalline. salmon calcitonin was efficiently associated with the nanocarriers and a notably high drug loading was achieved
  • CHON/PROT NPs released less than 10% of the total loaded peptide in the first hour of the in vitro release studies
  • The composition of medium and its ionic strength was found to have a considerable influence on the release of sCT from CHON/PROT NPs
  • Complexation to CHON markedly reduced the toxic effects exerted by PROT and the NPs were compatible and well tolerated by Caco-2 cells

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