Cyclodextrin solubilization of carbonic anhydrase inhibitor drugs: Formulation of dorzolamide eye drop microparticle suspension

Applied carbonic anhydrase inhibitors are commonly used to treat glaucoma

Phatsawee Jansook

2010

Scholarcy highlights

  • Applied carbonic anhydrase inhibitors are commonly used to treat glaucoma
  • Dorzolamide had the highest affinity for γ-cyclodextrin and, was selected for further investigation
  • Hydroxypropyl methylcellulose was the most effective polymer tested for stabilization of the dorzolamide/γCD complexes and gave the highest mucoadhesion at 0.5% w/v concentration
  • The in vivo testing of the formulation showed that the drug was delivered to the aqueous humor in rabbits for at least 24 h with the maximum drug concentration at 4 h. This formulation delivered the drug to the posterior segment of the eye after topical administration. These results indicate that this CAI eye drop formulation has the potential of being developed into a once-a-day product
  • These results indicate that this carbonic anhydrase inhibitors eye drop formulation has the potential of being developed into a once-a-day product

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