Improvement in physicochemical parameters of DPPC liposomes and increase in skin permeation of aciclovir and minoxidil by the addition of cationic polymers

1,2-Dipalmitoyl-sn-glycero-3-phosphocholine liposomes were prepared by high-pressure homogeniser and coated with two cationic polymers, chitosan and for the first time Eudragit EPO, respectively

Amra Hasanovic

2010

Scholarcy highlights

  • 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine liposomes were prepared by high-pressure homogeniser and coated with two cationic polymers, chitosan and for the first time Eudragit EPO, respectively
  • Influences of polymers and model drugs on thermotropic phase transition of DPPC liposomes were studied by micro-differential scanning calorimetry
  • The influences on configuration of DPPC liposomes were investigated by Fourier transform infrared spectroscopy
  • According to DSC results, cationic polymers had a stabilising effect, whereas aciclovir and minoxidil changed the physical properties of the DPPC bilayers by influencing the main phase transition temperature and erasing the pre-transition
  • The investigation of CO stretching bands of DPPC at 1736 cm−1 in FTIR spectra showed that aciclovir has strong hydrogen bonding with CO groups of DPPC, whereas carbonyl groups were free in minoxidil presence
  • This could be explained as an effect of positively charged liposomes to interact stronger with skin negatively charged surface and their possible interactions with structures below the stratum corneum

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