Formulation and characterization of an oily-based system for oral delivery of insulin

The present work explored the possibility of formulating an oral insulin delivery system by combining the advantages of nanoencapsulation and the use of oily vehicle

Amani Elsayed

2009

Scholarcy highlights

  • The present work explored the possibility of formulating an oral insulin delivery system by combining the advantages of nanoencapsulation and the use of oily vehicle
  • Insulin was protected from gastric enzymes by incorporation into lipid-based formulation
  • The results of RP HPLC and ELISA indicated that insulin was able to withstand the preparation procedure
  • Insulin in the preparations was stable for a period of one month at storage temperatures of 4 and 25 °C
  • Hypoglycemic effect of nanoparticles administered orally was sustained for a longer period of time compared to the subcutaneous injection
  • These results clearly evidenced the ability of the nanoparticles to enhance the pharmacological response of insulin when given orally and could be used to deliver other peptides

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