Design, synthesis, and evaluation of novel fluoroquinolone–flavonoid hybrids as potent antibiotics against drug-resistant microorganisms

Based on a rationally conceived pharmacophore model to build a multi-target bacterial topoisomerase inhibitor, twenty-one fluoroquinolone–flavonoid hybrids were synthesized

Zhu-Ping Xiao

2014

Scholarcy highlights

  • Based on a rationally conceived pharmacophore model to build a multi-target bacterial topoisomerase inhibitor, twenty-one fluoroquinolone–flavonoid hybrids were synthesized
  • They show a novel dual-mode action by inhibiting both DNA gyrase and efflux pump. These hybrids provide a new weapon against drug-resistant microorganisms
  • The introduced flavonoid moiety provides several additional interactions with DNA gyrase and significantly increase the drug accumulation in cell, suggesting that the hybrids show a dual mode of action

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