Malignant pleural mesothelioma: clinicopathologic and survival characteristics in a consecutive series of 394 patients☆

Malignant pleural mesothelioma is a relatively rare tumor, with a growing incidence over the last decades

Piero Borasio

2008

Scholarcy highlights

  • Malignant pleural mesothelioma is a relatively rare tumor, with a growing incidence over the last decades
  • The current single institution study was performed in order to investigate clinicopathologic characteristics and potential prognostic factors in patients with MPM, and to ascertain whether surgery followed by adjuvant therapy had an independent prognostic role
  • Median survival time and 2-year survival rate were 14.6 months and 23.6%, respectively, in patients with epithelial cell type, and 8.7 months and 11.9%, respectively, in patients with biphasic cell type
  • The patients with sarcomatous cell type had a significantly worse prognosis: median survival time 4.5 months, 2-year survival rate 0%
  • The prognosis of our series was dismal: overall median survival 11.9 months, 2year survival rate 18.8%
  • (3) The retrospective design of this study and the small number of patients undergoing multimodality therapy make it hard to decipher the role of surgical resection and adjuvant therapy in the treatment of MPM

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